Up until the end of the 1990s, Monsanto was mainly a company focussed on producing and selling chemical pesticides. These kill bugs quickly and indiscriminately, ideal for large, monoculture farms and routine spraying, albeit devastating for biodiversity and human health. Monsanto didn’t care at all about non-chemical pesticides like those made with the soil microbe Bacillus thuringiensis (Bt). So-called biopesticides, are slower acting and suited to smaller-scale production, with farmers monitoring the crops closely and spraying only when necessary. Though less harmful, biopesticides make much less money for companies, as they usually fall outside the patent industry’s grasp.Monsanto’s interest in Bt piqued with the advent of genetic engineering. The company realised it could insert genes from Bt into plants, enabling them to produce the toxin non-stop throughout the plant. This could, in effect, turn the biopesticide into something more akin to a chemical pesticide— well suited to industrial monocropping. And, on top of it, Monsanto could patent this genetically engineered Bt and integrate it into its broader strategy of dominating the seed industry.Organic farmers, who’d used Bt carefully for generations so as not to encourage insect resistance, knew that if Monsanto moved ahead with its plans, insect resistance would inevitably develop. Two decades later, with multiple species of insects resistant to Bt crops, we know that they were right.[1]Ironically, Monsanto, bought by Bayer in 2018, is now one of several pesticide companies aggressively trying to take over the global market for biopesticides. From just a handful of companies engaged in the sector a couple of decades ago, there are an estimated 1,200 companies today. Most of these are startups and medium sized companies, but all of the top agrochemical corporations are involved, such as Bayer, BASF, Corteva, FMC, The Mosaic Group, Syngenta, UPL and Yara.[2] They are moving aggressively into the sector in their typical fashion-- through buy-ups, licensing agreements and mergers (see Table 1).Growing corporate interestFarmers around the world have always invented and used blends of different natural products to protect their crops from insects or to help with the fertility of their soils. It is a practice as old as agriculture itself and the formulas for these "bioinputs" have been passed down through generations. Today, most farmers, especially in the global South, still use bioinputs they produce on their own farms.[3]It is only in recent years that agrochemical corporations have started to take interest in bioinputs, or, as they call them, “biologicals”. As the interest of agrochemical corporations in the sector has grown, so has the global market. In 2021, commercial bioinputs’ sales amounted about US$10 billion, which accounts for around 4% of the global agricultural input market. Analysts expect sales to double or even triple by 2028.[4]A good chunk of the global bioinput market is in fact already in the hands of the top pesticide companies. In 2022, Bayer sold US$214 million worth of bioinputs and it expects sales to reach US$1.6 billion by 2035.[5] Corteva says it sold US$420 million worth in 2023 and the Syngenta Group says it sold US$400 million.[6]These corporations and their competitors are mainly focussed on biopesticides, which are the biggest sellers, estimated to account for half of the global bioinputs market. The remainder of the market is made up of biofertilisers, which provide nutrients to plants, and biostimulants, which boost the plant's ability to absorb nutrients.[7] The companies are also fixated on just a few microbes. Bt-based products account for 90% of the global biopesticide market, while 60% of biofungicides contain Trichoderma spp.[8] When it comes to biofertilisers, Cyanobacteria, a blue-green algae with the ability to fix nitrogen and produce growth-promoting vitamins and enzymes, gets most of the attention.[9]The largest regional market for bioinputs is the US/Canada, followed by Asia-Pacific, Europe and Latin America. Brazil is one of the fastest growing markets, and a major focus of agrochemical companies. By June 2024, 1,273 agricultural bioinputs were registered for sale in the country, half of them for biopesticides and half for biofertilisers, and the vast majority for use on Brazil's top monoculture crops-- soybeans, maize and wheat.[10] Of these products, 82% were made by foreign companies, with Bayer alone accounting for 12%.[11] According to the Brazilian Ministry of agriculture, biofertilisers are currently applied on nearly 40 million hectares, and biopesticides are used on 10 million hectares.[12]What are bioinputs?Bioinputs include principally biopesticides, biofertilisers and biostimulants. It is generally agreed that they are all derived from two main sources: biochemical substances and living organisms (microbes and macroorganisms). The most common in the market are microbial bioinputs (using bacteria, fungi and viruses).[13] Subspecies and strains of Bacillus thuringiensis (Bt) are the most widely used, having been commercialised for decades.[14] Another microbe, the Rhizobacteria, has been used in biofertilisers since the nineteenth century.[15] However, there is no standard definition for bioinputs. In Brazil, the legislation defines it loosely as a product, process or technology of plant, animal or microbial origin for use in the production, storage and processing of agricultural products, aquatic production systems or planted forests.[16]A toxic agendaWhat's behind this newfound interest in bioinputs among the agrochemical giants? In the case of biopesticides, a main factor is that they are cheaper and faster to bring to market than chemical pesticides. In the US, the development of a new biopesticide costs between US$3 to US$7 million and can be commercialised in four years, while a chemical pesticide takes three times as long to develop, and can cost more than US$280 million. Increasing bans on toxic pesticides and lawsuits (such as the one over Roundup) are another reason, along with costs along the supply chain that can be lower for biopesticides than for fossil-fuel based agrochemicals. In addition, biological resistance to chemical pesticides is increasing as a result of their massive use in monocultures.[17]The agrochemical corporations are also interested in integrating bioinputs into their digital platforms, which are increasingly connected with "regenerative agriculture" and "carbon farming" programmes that they offer to farmers and downstream food companies. Bayer, for example, sells biopesticides and biostimulants, but is also moving into the field of fertilisers by investing in engineered nitrogen-fixing bacteria. Bioinputs are integrated in its strategy for regenerative agriculture, carbon farming, gene editing and digital platforms. The “farm of the future” package it plans to sell includes a system where a farmer supposed to do regenerative agriculture uses Bayer’s gene edited maize and soybean. Then, through their digital platform the farmer gets “tailored” recommendations from Microsoft Azure based on historic data. The farmer is supposed to harvest cover crops as low carbon biofuel and to sell carbon credits via the corporations’ carbon programme.[18] The Indian fertiliser company UPL has similar plans through their “Nurture.farm” digital platform.[19]But we should not confuse the interest agrochemical corporations now have in bioinputs with any turn away from their toxic chemicals. While farmers have traditionally used bioinputs as an additional strategy to manage pests and diseases, using them sparingly to avoid the development of resistance and the destruction of biodiversity, agrochemical companies want farmers to use their biopesticides in the same manner that they use their chemical pesticides-- applying heavy doses in a routine manner as the means of killing any and all bugs. Indeed, for companies like Bayer, bioinputs are complementary to its agrochemical package.[20] In 2016, it developed a 'toolbox' that includes both chemical pesticides and biopesticides in a digital platform designed to assess how the products should be combined. Part of the package for farmers participating in the programme are drip irrigation systems, designed by the Israeli company Netafim. It was first marketed in Mexico, where a partnership with PepsiCo was signed, and then expanded to the Mediterranean region, Australia, South Africa, Brazil and Chile, and more recently China and Vietnam.[21]FMC Corp, one of the largest US-based agrochemical companies, says it will sell bioinputs "in concert” with agrochemicals, and has even developed a Bt biopesticide (Ethos Elite LFR) which includes synthetic insecticide and fungicide.[22]The same logic applies to biofertilisers. For example, in 2023, Yara launched a biostimulant “to complement” its fertiliser portfolio, and Novonesis recommends the “co-application” of biofertilisers and chemical fertilisers.[23]And there is another important factor driving agrochemical corporations into the bioinputs market. Advances in gene editing, synthetic biology and data science make it easier for corporations to identify microbes of interest, develop bioinputs from them, and, perhaps most importantly, secure monopoly control through patents (See Box: Monopoly games).[24] The corporations are betting that they will be able to bring these genetically modified products onto market without any regulatory obstacles.Monopoly gamesBetween 2000 and 2023, more than 44,000 patent applications for bioinputs have been registered worldwide. Biofertilisers appear to account for two-thirds of the applications, but this figure needs to be nuanced as there is overlap with biopesticides in a significant number of cases. China has led the way by a wide margin, accounting for 80% of all applications. But 97% of the applications in China were exclusively presented at the domestic level, and mostly made by Chinese universities.[25]The number of patent applications filed in more than one country is a good indicator of the main markets for corporate players. The principal countries where patents are sought for bioinputs are the US, the European Union, China, Australia, Canada, Brazil, Japan, India, Mexico, South Korea, Spain, Argentina, South Africa, Russia and Germany. Bayer is far and away the leader in terms of applications in more than one country. It is followed by a handful of agribusiness giants and a mix of lesser-known agri-tech companies: BASF, Novonesis (former Novozymes), Pivot Bio, Newleaf Symbiotic, Marrone Bio, Valent Biosciences, Locus Agriculture IP Company, Danstar ferment, Syngenta, FMC, Idemitsu Kosan, Spogen Biotech and Sumitomo Chemical.[26] The corporate rush into the bioinput market could trigger a new wave of life form privatisation, many of which have been used by peasant communities. Patents on processes and genetic sequences of microorganisms will create a corporate-led bioinput market, granting monopoly rights to patent holders. This means that those who wish to use products containing certain patented products or processes must obtain authorisation or pay for their use. This can result in farmers being heavily fined and even imprisoned.[27]Playing the sorcerer's apprentice with microbesThe involvement of agrochemical corporations in genetically modifying microbes for bioinputs goes back at least a decade. The Japanese giant Sumitomo Chemical acquired Valent BioSciences, a developer of genetically modified (GM) Bt biopesticides in 2013.[28] Bayer, for its part, has a joint venture with Ginkgo Bioworks, called Joyn Bio, that is developing a nitrogen-producting GM microbe for maize, rice and wheat.[29]“We can go look at the genome of the microbe of the soy, read the DNA code, find the part of it that says 'Hey, here's how you produce fertiliser', go on the computer, redesign it, hit print, and then install that code into microbes that live on the roots of corn. That’s the project we’ve been working on with Bayer”, explains Jason Kelly, Ginkgo Bioworks’ CEO.[30]Bayer is also supporting Eduardo Blumwald's Laboratory at the University of California, Davis, to develop GM biostimulants for rice plants using the CRISPR gene editing technique.[31]Another example lies in US startup Agbiome, which develops GM microbe-based bioinputs. Monsanto Growth Ventures were among its early investors.[32] More recently, Agbiome has signed partnerships with Mosaic, BASF and Genective (a joint venture between Limagrain and KWS), and Ginkgo Bioworks just announced its intention of acquiring the company.[33]Some of these agrochemical corporation partnerships have already brought GM bioinputs to market, although because of a lack of transparency by both companies and regulators, it is not easy to identify those that have been commercialised or that are in the process of being approved.[34]Brazil's MST (Landless Workers Movement) giving their own bioinput training.Friends of the Earth recently identified two such products that have been commercialised in the US. One is a GM bacteria-based biofertiliser called Proven that is produced by Pivot Bio, a US company backed by Monsanto Growth Ventures. Proven was the first genetically engineered (GE) microbe to be widely commercialised, back in 2019. The US authorities are meant to oversee new biotechnology products, to ensure they are safe for the environment and human and animal health.[35] But they decided not to regulate Proven, arguing that the wild form of the bacteria was not a pathogen and it was not engineered with foreign DNA. The other is a GM Bt seed treatment produced by BASF, as Poncho/VOTiVO. Although it is sold in a mixture with a highly problematic neonicotinoid insecticide that is toxic to beneficial insects, BASF succeeded in having it registered as a biostimulant, thereby avoiding the more stringent oversight that exists for biopesticides.[36]As Friends of the Earth points out, the mass introduction of such GM microbes without meaningful regulatory oversight is of grave concern. These GM microbes are living organisms that can reproduce and interact with other species (for example by spreading to other microbes via horizontal gene transfer) in unpredictable ways. And the scale of the risk is even greater than for GM crops. Whereas three trillion GM maize plants are grown each year in the US, an application of GM bacteria can release the same number of GM organisms on just two hectares. The inability to contain the GM microbes also raises important environmental concerns, as well as risks for farmers who could wind up being sued by companies if patented GM microbes trespass onto their fields, as has happened with GM crops.[37] Added to this are the risks of resistance developing to conventional biopesticides or the health and environmental risks of the non-active ingredients used in the formulations of bioinputs, which are amplified when used in high volumes and across large areas.[38]Surfing on different regulationsBeyond bioinputs, at the legal level, corporate lobbies are doing everything they can to prevent genetically engineered products from being considered GM. But this distinction is absurd because genetic manipulation poses the same risks in both cases.[39] Consequently, international legislation requires that any product developed through genome modification using modern biotechnology, even if the end product does not contain a foreign gene, must undergo health and environmental risk assessment and, if commercialised, labelling and monitoring.[40]It is hardly surprising that the bioinput market is expanding most rapidly in countries like the United States, Brazil and Japan, where GM bioinputs can be commercialised without any assessment of their potential impact on the environment and health, and worse, without any means of identifying them.[41]“It’s amazing the number of products that they [the Brazilian authorities] have been able to register in a short period of time [due to] policies that have been implemented to enable that to happen,” said recently Terry Stone of Corteva Agriscience, referring to bioinputs.[42]Brazil's market has doubled since 2020, when a National Bioinputs Programme was introduced.[43] Bioinputs, including those produced through genetic modification, can move through the regulatory process and be registered in less than 10 months in some cases.[44] Not only are there no obstacles for using GM microorganisms in bioinputs production, but an increasing number of GM products entering the country are not being defined as transgenic by the authorities because they are produced by genetic editing techniques that do not involve the insertion of genetic material from foreign organisms.[45] Over the past few years, 9 of the 65 genetically modified products classified by Brazil's National Technical Biosafety Commission (CTNBio) as non-transgenic were bioinputs.[46]Most of the biopesticides registered in the country are toxicologically classified as unlikely to cause harm and of low risk to the environment. Many have been approved for use in organic agriculture, which strictly prohibits the use of genetically modified organisms, including those produced through gene editing. Although Brazilian legislation requires a technical-scientific report before a new bioinput can be registered, this analysis only looks at agricultural viability and efficiency and not at its biosafety. Therefore, under the current regulation, it is impossible to know whether bioinputs are the result of genetic engineering, nor to know the scientific basis for this classification as it relates to health and environmental risks.In the US, the Environmental Protection Agency regulates biopesticides under the same framework as chemical pesticides, but through a faster and cheaper registration process that can take less than a year. There are also no regulations that consider the specific properties of GM microbes and the same standards are used for chemical pesticides and microbes (GE or non-GM). In 2021, with the introduction of the “Sustainable, ecological, consistent, uniform, responsible, efficient” (SECURE) rule covering plant biotechnology regulations, a number of exemptions were made for the regulation of GM microbes, giving companies the right to judge for themselves if their product should be exempt from GM regulations and to sell microbes without oversight. Once GM microbes are released into the environment, there is no system to monitor their impact.[47]Until recently, regulation was more stringent in the EU. Biostimulants are included in the fertiliser regulation, which limits the concentration of contaminants such as mercury, nickel, copper and zinc. It also restricts the development of biostimulants to four types of microorganisms, and they are not allowed to undergo any treatment other than drying or freeze-drying.[48] For biopesticides, they must still meet the authorisation criteria of the pesticides legislation, but a simplified authorisation procedure for microbial products has been approved for 2022.[49] Nevertheless, in the near future bioinputs may be affected by the GMO lobbying of large chemical and seed companies (See Box: European deregulation of new GMOs).Things are also shifting in China, where biopesticides must still undergo environmental and health risk assessments to be registered, including field studies and assessments of maximum residue limits in food. But Chinese universities and companies, among them Syngenta, are world leaders in patents for agricultural bioinputs, and the Chinese government now encourages companies to develop and use biopesticides, offering 'fast-track' registration with less data requirements and reduced testing time. Overall, China is loosening its regulations on GM crops and, in 2017, the first biopesticide based on a genetically modified microbe (Bt G033A) was approved, although not for organic farming. Since 2022, genetically modified plants and products not considered transgenic can be registered for production and marketing without evaluation, just like conventional products.[50]Worldwide, the debate on regulating bioinputs is complex and should draw on lessons learned from the fight against GMOs. There is a real risk that regulating the use, registration, transport and commercialisation of bioinputs could lead to the criminalisation of traditional farming practices. Strict regulation can make processes more expensive and strengthen corporate monopoly control. On the other hand, lax regulation can result in inadequate testing and increased risks of contamination or genetic modification. In any case, it’s crucial to preserve the free use of bioinputs produced by peasant and indigenous farmers.A progressive legislative initiative is currently under discussion in Bolivia, promoted by Probioma, an association engaged in social mobilisation against GM crop expansion and in favour of agroecological practices. Probioma has been producing biofertilisers and biopesticides for thirty years, eschewing the corporate approach by not registering any patents. The proposed law on bioinputs aims to promote research and development of bioinputs to strengthen agroecological production and guarantee food sovereignty and security. However, the law includes elements that need to be carefully assessed due to potential risks of biopiracy and restrictions on farmers’ free use of products. It proposes creating a national certification system for bioinputs, with a differentiated register for those produced by peasant and indigenous agriculture. Registration for this sector would be voluntary and free of charge, except when the products are intended for commercialisation. Proponents of the law emphasise that it is grounded in a rejection of GMOs and seeks to prevent the authorisation of genetic engineering in the production of bioinputs.[51]European deregulation of new GMOsLast year, the European Commission proposed effectively deregulating "new genomic techniques" (NGT), which would exclude these genetically edited or modified organisms from existing GMO legislation. Currently, GMOs require authorisation to ensure risk assessment for human health and the environment, as well as adherence to labelling and traceability requirements. Despite opposition from NGO’s, scientists, and some farmers' organisations, the European Parliament voted in favour of deregulating GMOs produced with NTGs.[52] While the Parliament supported labelling and detection -seen as a small victory for civil society- these measures rely on declarations from the industry. There is no obligation to publish the methods for detecting and identifying these products.[53] New genomic techniques remain prohibited in organic production. The debate continues, as the Council of Agriculture Ministers has failed to reach an agreement on this deregulation plan, largely due to concerns about patents on NGTs raised by farmers’ organisations.[54]Agroecology is once again the answerIndustrial agriculture drives the climate crisis and numerous other global issues.[55] These problems won’t be solved by merely reducing pesticides and chemical fertilisers. They stem from the model and scale of industrial agriculture, which is embedded in a predatory and unjust global food system controlled by a few corporations.If these same corporations take over bioputs, they will simply create a new business niche that won’t eliminate toxic agrochemicals but, on the contrary, extend their complementary use. Worse, corporate bioinputs are part of the false solutions to the climate crisis, wrapped in the new “green” packages of regenerative agriculture and agriculture digitalisation.[56]What is needed is a shift to agroecology, grounded on farmer knowledge, collective innovation and food sovereignty. We must reject expensive, patented corporate techno-fixes that only perpetuate industrial agriculture and its devastating consequences.Banner photo: Introduction of Bt (Bacillus thuringiensis) corn in Kenya (2003).Creative commonsTable 1. Some agrochemical company deals in the bioinput sectorCompanyNotesAgbiome (USA)Monsanto Growth Ventures was its first investor in 2013 (US$17,5 million), followed by the Gates Foundation in 2015 (US$34,5 million). More recently, Agbiome has signed partnerships with The Mosaic Company, BASF and Genective (a joint venture between Limagrain and KWS), and Ginkgo Bioworks just announced its intention of acquiring the company.AgraQuest (USA)US supplier of biopesticides. Acquired by Bayer in 2012 for US$425 million. Developed Bayer's number one bioinput, the biofungicide Serenade for fruits and vegetables.Agrivalle (Brazil)Major seller of bioinputs in Brazil. In 2023, it partnered with Ginkgo Bioworks to improve the biofungicide Agrivalle already sold in the country.Andes (USA)Since 2021, Bayer and Cavallo Ventures injected US$15 million in this startup to produce biofertilisers.Biagro Group (Argentina)Acquired by Bayer in 2014.Bioceres (Argentina)In 2022, Bioceres and the US bioinputs firm Marrone Bio Innovation merged.In 2023, Bioceres and Corteva signed an agreement to commercialise in Europe a biopesticide developed by Bioceres' subsidiary Pro Farm.BioConsortia (USA)Has signed agreements since 2020 with The Mosaic Group to develop GE Microbes.De Sangosse Group (France)In 2024, Bayer signed a new agreement with the UK based company AlphaBio Control (which belongs to De Sangosse Group), for the license of a new biopesticide targeting coleoptera insects in oilseed rape and cereal crops. Bayer has already been distributing another AlphaBio biopesticide for several years.Evogene (Israel)Since 2019, Corteva has been investing in Lavie Bio Ltd. (Evogene’s subsidiary). In 2023, both signed a partnership to develop biofungicides with AI.Ginkgo Bioworks (USA)In 2017, Bayer announced a partnership with this company to create a new company that will develop microbials to enhance nitrogen-fixation in plants. In 2022, Bayer signed an agreement with Ginkgo Bioworks to expand its agricultural biologics platform, with a collaboration that will focus on advancing Joyn's nitrogen fixation program, as well as new programs in areas such as crop protection and carbon sequestration. In 2024, Syngenta announced a new partnership with Ginkgo Bioworks for large-scale bioinput production.Kimitec Group (Spain)Signed a partnership with UPL in 2022 to commercialise bioinputs in the US.Started in 2023 a partnership with Bayer to commercialise biopesticides and biostimulants. Has subsidiaries in China, North America and Latin America.Lallemand (Canada)Collaborates since 2017 with BASF and bought in 2024 the corporations’ San Diego-based bioenergy enzymes business.MustGrow Biologics Corp. (Canada)Has signed partnerships in 2022 and 2023 with Bayer to commercialise biopesticides for banana and potato plantations in Europe, west Asia and Africa.Has also partnerships with Sumitomo Corporation, Janssen PMP, and NexusBioAg, to distribute its bioinputs.Novonesis (former Novozymes, Denmark)One of the world's largest producer of enzymes. Signed a partnership in 2012 with Syngenta to develop a biofungicide launched in 2020.Launched the BioAg Alliance with Monsanto in 2013. In 2019, signed partnerships with UPL.Signed a partnership in 2021 with FMC to develop and commercialise enzyme-based biopesticides.Pivot Bio (USA)Since 2016, has attracted investments from Monsanto Growth Ventures, Temasek, Bunge, Bill Gates, Jeff Bezos, Mark Zuckerberg, among others.Sound Agriculture (USA)Signed an agreement in 2020 with the Mosaic Group to develop and distribute microbial biofertilisers for soybean and corn in the US, Brazil, Argentina and Canada.In 2021, jointly with Syngenta Ventures and others, Bayer invested US$45 million in this firm for producing a “bio-inspired” fertiliser (not strictly a biofertiliser).Stoller (USA)Was acquired by Corteva in 2022 for US$1.2 billion.Symbiomics (Brazil)Signed a partnership with Corteva, and is supported by venture capital managers such as Yield Lab Latam, Vesper, Mov Investimentos, Baraúna Investimentos and Ecoa Capital.Symborg (Spain)Had agreements with Corteva to distribute biofertlisers in Europe and Israel, and was finally acquired by the corporation in 2022.Data compiled by GRAIN from company and media sources._____________________________________ [1]Eva Sirinathsinghji, “Bt crops past their sell-by date: a failing technology searching for new markets?”, TWN Biotechnology & Biosafety Series, 2022, https://www.twn.my/title2/biosafety/pdf/bio19.pdf[2]The Mixing Bowl, “2023 Ag Biologicals Landscape”, 2023, https://www.mixingbowlhub.com/landscape/2023-ag-biologicals-landscape[3]FAO, “Bioinsumos. Oportunidades de inversión en América Latina”, 2023, https://openknowledge.fao.org/server/api/core/bitstreams/6f0feb21-441d-4662-aed5-03085a951d90/content[4]See: FAO, “Bioinsumos. Oportunidades de inversión en América Latina”, 2023, https://openknowledge.fao.org/server/api/core/bitstreams/6f0feb21-441d-4662-aed5-03085a951d90/content; Fortune Business Insights, “Agricultural Biologicals Market, 2022-2029”, 2023, https://www.globenewswire.com/news-release/2023/06/05/2681944/0/en/Agricultural-Biologicals-Market-to-Hit-USD-29-31-Billion-by-2029-Fortune-Business-Insights.html; MarketResearch Biz, “Agricultural Biologicals Market”, 2023, https://marketresearch.biz/report/agricultural-biologicals-market/[5]See: Bayer, “Bayer to deliver ten blockbusters in ten years”, 17 June 2024, https://www.bayer.com/en/us/news-stories/2024-ag-innovation-update; Bayer, “2023 Annual report”, 2024, https://www.bayer.com/en/investors/integrated-annual-reports; Horti Daily, “Biologicals are part of the solution to secure global food supply”, 30 October 2015, https://www.hortidaily.com/article/6021595/biologicals-are-part-of-the-solution-to-secure-global-food-supply/[6]See: Corteva Agriscience, “2023 Annual report”, 2024, https://investors.corteva.com/static-files/e34e5b8f-833c-4b8c-9222-6d57245db918; Syngenta Group, “Syngenta Group reports $32.2 billion sales and $4.6 billion EBITDA in 2023”, 29 March 2024, https://www.syngentagroup.com/newsroom/2024/syngenta-group-reports-322-billion-sales-and-46-billion-ebitda-2023[7]See: Fortune Business Insights, “Agricultural Biologicals Market, 2022-2029”, 2023, https://www.globenewswire.com/news-release/2023/06/05/2681944/0/en/Agricultural-Biologicals-Market-to-Hit-USD-29-31-Billion-by-2029-Fortune-Business-Insights.html; MarketResearch Biz, “Agricultural Biologicals Market”, 2023, https://marketresearch.biz/report/agricultural-biologicals-market/[8]FAO, “Bioinsumos. Oportunidades de inversión en América Latina”, 2023, https://openknowledge.fao.org/server/api/core/bitstreams/6f0feb21-441d-4662-aed5-03085a951d90/content[9]Research and Markets, “Global biofertilizer market report by type, crop, microorganism, mode of application, and region 2024-2032”, April 2024, https://www.researchandmarkets.com/reports/5530496/global-biofertilizer-market-report-by-type#src-pos-16[10]National Bioinputs Catalogue application with information on biopesticides and biofertilisers/inoculants registered with the Ministry of Agriculture and Livestock, developed in partnership with Embrapa Digital Agriculture to implement the National Bioinputs Programme provided for in Decree 10.375/2020. https://www.gov.br/agricultura/pt-br/assuntos/inovacao/bioinsumos/o-programa/catalogo-nacional-de-bioinsumos[11]Instituto Nacional da Propiedade Industrial (INPI), “Radar tecnológico. Bioinsumos na agricultura: inoculantes”, 2023, https://www.gov.br/inpi/pt-br/central-de-conteudo/noticias/inpi-divulga-nova-edicao-do-radar-tecnologico-sobre-bioinsumos-na-agricultura-inoculantes[12]Embrapa, “Bioinsumos: Tendência de crescimento no Brasil”, 8 December 2023, https://www.embrapa.br/busca-de-noticias/-/noticia/85620702/bioinsumos-tendencia-de-crescimento-no-brasil[13]See: Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/; AgFunder, “Biological progress or bathtub brews? The state of US crop biologicals in 2024”, 21 March 2024, https://agfundernews.com/biological-progress-or-bathtub-brews-the-state-of-us-crop-biologicals-in-2024; The Mixing Bowl, “2023 Ag Biologicals Landscape”, 2023, https://www.mixingbowlhub.com/landscape/2023-ag-biologicals-landscape[14]See: EPA, “What are biopesticides?”, n/d, https://www.epa.gov/ingredients-used-pesticide-products/what-are-biopesticides; Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[15]ETC Group, “Food barons 2022. Crisis profiteering, digitalization and shifting power”, 2022, https://etcgroup.org/content/food-barons-2022[16]For a more detailed definition, see: Ministerio da Agricultura e Pecuária, “Bioinsumos”, n/d, https://www.gov.br/agricultura/pt-br/assuntos/inovacao/bioinsumos[17]Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[18]Bayer, “Bayer crop science sustainability progress report”, October 2023, https://www.bayer.com/sites/default/files/october-24-2023-sustainability-progress-report-1.pdf[19]See: https://nurture.farm/farm/[20]See: Bayer, “Innovation inspired by nature”, n/d, https://www.bayer.com/en/agriculture/agriculture-biologicals; AgFunder, “Q&A w/ Bayer: ‘It would be detrimental to take chemical crop protection out of the toolbox’”, 5 july 2023, https://agfundernews.com/qa-w-bayer-it-would-be-detrimental-to-take-chemical-crop-protection-out-of-the-toolbox[21]See: Bayer, “Looking below ground level with Root2Success: Managing root health in horticulture crops in a sustainable manner”, n/d, https://www.bayer.com/en/agriculture/article/sustainable-root-management-agricultural-productivity; AgNews, “Bayer launches its first biofungicide Serenade to Chinese market”, 3 March 2020, https://news.agropages.com/News/NewsDetail---34380.htm; Bayer, “The Bayer’s newly launched bio-fungicide product amplifies crop yield and quality, offering an effective, safe and environment-friendly crop protection solution for Vietnamese farmers”, 31 October 2023, https://www.bayer.com/en/vn/bayer-newly-launched-bio-fungicide-product[22]Eric Sfiligoj, “Biologicals in row crops: building towards a brighter future”, CropLife, 23 April 2024, https://www.croplife.com/crop-inputs/biologicals-in-row-crops-building-towards-a-brighter-future/[23]See: https://www.yara.com/knowledge-grows/growing-more-resilient-crops-with-biostimulants/; Muhammad Arsalan, “Integration of biofertilizers with chemical fertilizers: an environmental friendly approach towards sustainable agriculture”, LinkedIn, 11 May 2023, https://www.linkedin.com/pulse/integration-biofertilizers-chemical-fertilizers-friendly-arsalan/[24]ETC Group, “Food barons 2022. Crisis profiteering, digitalization and shifting power”, 2022, https://etcgroup.org/content/food-barons-2022[25]Instituto Nacional da Propiedade Industrial (INPI), “Radar tecnológico. Bioinsumos na agricultura: inoculantes”, 2023, https://www.gov.br/inpi/pt-br/central-de-conteudo/noticias/inpi-divulga-nova-edicao-do-radar-tecnologico-sobre-bioinsumos-na-agricultura-inoculantes[26]Instituto Nacional da Propiedade Industrial (INPI), “Radar tecnológico. Bioinsumos na agricultura: inoculantes”, 2023, https://www.gov.br/inpi/pt-br/central-de-conteudo/noticias/inpi-divulga-nova-edicao-do-radar-tecnologico-sobre-bioinsumos-na-agricultura-inoculantes[27]La Via Campesina and GRAIN, “Seed laws that criminalise farmers: resistance and fightback”, 8 April 2015, https://grain.org/e/5142[28]See: Antonina Sorokan, et. al. “Genetic engineering approach for next-generation of Bt-based agents”, 6 December 2023, https://encyclopedia.pub/entry/52379; NON GMO Project, “ New GMO Alert: gene-edited microbes introduce a new twist in GMO agriculture”, n/d, https://www.nongmoproject.org/blog/new-gmo-alert-gene-edited-microbes-introduce-a-new-twist-in-gmo-agriculture/[29]See: Bayer, “Bayer and Ginkgo Bioworks close deal creating Agricultural Biologicals Powerhouse”, 18 October 2022, https://www.bayer.com/media/en-us/bayer-and-ginkgo-bioworks-close-deal-creating-agricultural-biologicals-powerhouse/; Matt Blois, “Can microbes replace synthetic fertilizer?”, Chemical & Engineering News, 31 July 2023, https://cen.acs.org/food/agriculture/microbes-replace-synthetic-fertilizer/101/i25; Elie Dolgin, “Bioengineers aim to break Big Ag’s addiction to fertilizers”, IEEE Spectrum, 31 May 2018, https://spectrum.ieee.org/bioengineers-aim-to-break-big-ags-addiction-to-fertilizers[30]Bayer, “Bayer biologics: innovation through partnership”, 2023, https://youtu.be/NucK4Xd6GCg?feature=shared[31]Eduardo Blumwald's Laboratory, “Projects”, n/d, https://blumwald.ucdavis.edu/research-projects[32]Louisa Burwood-Taylor, “Bill & Melinda Gates Foundation makes first agtech investment in AgBiome’s $34.5m series B”, AgFunder, 20 August 2015, https://agfundernews.com/bill-melinda-gates-foundation-first-agtech-investment-agbiome-011[33]See: ETC Group, “Food barons 2022. Crisis profiteering, digitalization and shifting power”, 2022, https://etcgroup.org/content/food-barons-2022; Jennifer Marston, “The Week in AgriFoodTech: Windfall Bio scoops up $28m, TerraClear bags $15m, Ginkgo buys AgBiome assets”, 11 April 2024, https://agfundernews.com/the-week-in-agrifoodtech-windfall-bio-scoops-up-28m-terraclear-bags-15m-ginkgo-buys-agbiome-assets[34]Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[35]USDA, “Regulation of biotech plants”, n/d, https://www.usda.gov/topics/biotechnology/how-federal-government-regulates-biotech-plants[36]Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[37]Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[38]For more information on the risks of GM microorganisms, see: “Les Micro-organismes Génétiquement Modifiés, avec Christophe Noisette”, Le Goût du Rêve, 26 July 2024, https://youtu.be/371yazJf5pU[39]Corporate Europe Observatory, “Biotech lobby’s push for new GMOs to escape regulation”, 2 February 2016, https://corporateeurope.org/en/food-and-agriculture/2016/02/biotech-lobby-push-new-gmos-escape-regulation[40]The Cartagena Protocol on biosafety defines as living modified organism “any living organism that possessesa novel combination of genetic material obtained through the use of modern biotechnology” (see: https://www.cbd.int/doc/legal/cartagena-protocol-en.pdf).[41]2BMonthly, “Is the EU regulatory framework providing a benefit yet for biological companies?”, AgriBusiness Global, 13 February 2024, https://www.agribusinessglobal.com/markets/is-the-eu-regulatory-framework-providing-a-benefit-yet-for-biological-companies/[42]Jennifer Marston, “‘The pressure is on’ as ag biologicals evolve past ‘the peak of inflated expectations’”, AgFunder, 2 July 2024, https://agfundernews.com/the-pressure-is-on-as-ag-biologicals-evolve-past-the-peak-of-inflated-expectations[43]Embrapa, "Bioinputs: Growth trend in Brazil", 8 December 2023, https://www.embrapa.br/busca-de-noticias/-/noticia/85620702/bioinsumos-tendencia-de-crescimento-no-brasil[44]Rick Melnick, “Brazil’s strong showing”, AgriBusiness Global, n/d, https://www.agribusinessglobal.com/special-sections/brazils-strong-showing/[45]National Technical Biosafety Commission (CTNBio), “Liberações Comerciais. Micro-organismos geneticamente modificados e seus derivados aprovados comercialmente para uso comercial no brasil”, http://ctnbio.mctic.gov.br/liberacao-comercial[46]National Technical Biosafety Commission (CTNBio), “Tecnologias inovadoras de melhoramento genético (RN16)”, http://ctnbio.mctic.gov.br/tecnologias-inovadoras-de-melhoramento-genetico-rn16-[47]Friends of the Earth, “Genetically engineered soil microbes: risks and concerns”, August 2023, https://foe.org/news/ge-soil-microbes-report/[48]See: https://eur-lex.europa.eu/legal-content/ES/TXT/PDF/?uri=CELEX:32019R1009[49]See: https://ec.europa.eu/commission/presscorner/detail/en/qanda_22_852; and https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex%3A32009R1107[50]See: Reach24h, “China biological pesticides: compliance suggestions and market analysis”, 13 April 2022, https://www.reach24h.com/en/news/industry-news/agrochemical/compliance-suggestions-for-china-biological-pesticides.html; CIRS Agrochemicals, “China microbial pesticide registration”, n/d, https://www.cirs-group.com/en/agrochemicals/china-microbial-pesticide-registration; Chemlinked, “China MoARA drafts active ingredient list to facilitate biopesticide registration”, 20 March 2020, https://agrochemical.chemlinked.com/news/china-moara-drafts-active-ingredient-list-facilitate-biopesticide-registration[51]Sources: Personal communication by Miguel Ángel Crespo, member of the board, Probioma; Probioma, “Presentan proyecto de ley para la fabricación y uso de bioinsumos agroecológicos”, 10 May 2023, http://probiomabolivia.blogspot.com/2023/05/presentan-proyecto-de-ley-para-la.html[52]See: https://www.europarl.europa.eu/doceo/document/TA-9-2024-0325_EN.pdf[53]See: Eurovia, “Press release - European Parliament votes on GMOs/NGTs and seeds: Repeated violations of peasants' rights”, 25 April 2024, https://www.eurovia.org/press-releases/european-parliament-votes-on-gmo-ngt-and-seeds-repeated-violations-of-peasants-rights/ ; Corporate Europe Observatory, “Take action! New GMOs need to stay checked for safety and labelled”, 15 January 2024, https://corporateeurope.org/en/2024/01/take-action-new-gmos-need-stay-checked-safety-and-labelled; Demeter, “New GMOs: old claims and false promises. Briefing paper – proposal on new genomic techniques”, 22 August 2023, https://demeter.net/new-gmos-old-claims-false-promises/[54]Sources: Personal communication by European Coordination Via Campesina and the Corporate Europe Observatory; Greenpeace, “EU food safety watchdog backs controversial Commission plan on new GMO plants”, 11 July 2024, https://www.greenpeace.org/eu-unit/issues/nature-food/47140/eu-food-safety-watchdog-backs-controversial-commission-plan-on-new-gmo-plants/[55]GRAIN, “New poster on food and the climate crisis”, 2024, https://grain.org/e/7128[56]See: GRAIN, “Regenerative agriculture was a good idea, until corporations got hold of it”, 1 December 2023, https://grain.org/e/7067; GRAIN, “An agribusiness greenwashing glossary”, 7 September 2022, https://grain.org/e/6877